Patient presented with sudden painful erythematous lesions on the face and neck and was urgently referred to dermatology after initial clinical evaluation. Recent medication was discontinued due to suspected drug-related reaction.<\/p>\n
Workup included skin biopsy, complete blood count, and testing for antibodies, lupus anticoagulant, and serological markers. Oral corticosteroids were started for symptom control.<\/p>\n
Within 48 hours, lesions improved significantly and pain subsided. Laboratory results showed leukocytosis with neutrophilia, positive antibodies and lupus anticoagulant, while routine serology remained negative.<\/p>\n
Skin biopsy findings obtained later confirmed the diagnosis of Sweet syndrome.<\/p>\n
Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition characterized by dense neutrophilic infiltration in the skin and sudden onset of painful erythematous papules or plaques.<\/p>\n
Its exact cause is unclear, but it is believed to involve cytokine-driven neutrophil activation. It is considered an immune-mediated hypersensitivity reaction associated with infections, malignancies, or drug exposure.<\/p>\n
Drug-induced cases are relatively common and may be linked to medications such as antibiotics, antiepileptics, contraceptives, antihypertensives, vaccines, and colony-stimulating factors. First-line treatment is oral corticosteroids, often producing rapid clinical improvement.<\/p>\n
Differential diagnosis includes urticaria, contact dermatitis, toxicoderma, and cutaneous lupus. Definitive diagnosis requires correlation of clinical presentation, laboratory findings, and histopathology to exclude systemic disease and guide appropriate therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"
Patient presented with sudden painful erythematous lesions on the face and neck and was urgently referred to dermatology after initial clinical evaluation. Recent medication was discontinued due to suspected drug-related reaction. Workup included skin biopsy, complete blood count, and testing for antibodies, lupus anticoagulant, and serological markers. Oral corticosteroids were started for symptom control. Within […]<\/p>\n","protected":false},"author":1,"featured_media":9071,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-9070","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts\/9070","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9070"}],"version-history":[{"count":1,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts\/9070\/revisions"}],"predecessor-version":[{"id":9072,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts\/9070\/revisions\/9072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/media\/9071"}],"wp:attachment":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9070"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9070"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9070"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}