Sweet Syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder with systemic manifestations. Although uncommon, it is critical for primary care physicians to recognize its clinical signs and consider it during differential diagnosis\u2014especially when symptoms rapidly follow medication changes.<\/p>\n
This article outlines a documented clinical case and offers a comprehensive review of Sweet Syndrome, including its presentation, diagnostic criteria, treatment, and clinical significance, particularly in relation to medication-induced reactions.<\/p>\n
Clinical Case Summary<\/p>\n
A 55-year-old female patient with a medical history of hypertension and chronic obstructive pulmonary disease (COPD) presented with erythematous, painful facial and neck lesions accompanied by low-grade fever. She had no known allergies and reported smoking approximately 10 cigarettes daily.
\nHer regular medication regimen included:<\/p>\n
Enalapril (6 years)
\nInhaled formoterol (2 years)
\nDue to a deterioration in pulmonary function, her pulmonologist replaced formoterol with a combination of indacaterol and glycopyrronium in capsule inhaler form.<\/p>\n
On the second day of the new therapy, the patient developed painful, reddish skin lesions on her cheeks and neck, prompting a visit to her primary care clinic. She denied recent upper respiratory infection symptoms, had used appropriate sun protection, and made no changes to her diet or cosmetic routine.
\nReferral and Diagnostic Workup<\/p>\n
Given the sudden onset and severity of symptoms, the patient was referred urgently to the Dermatology Department. The specialist recommended discontinuation of the new inhaled medication, conducted a skin biopsy, and ordered laboratory testing, including:
\nComplete blood count (CBC)
\nAutoimmune panel (e.g., antinuclear antibodies)
\nLupus anticoagulant
\nInfectious serology
\nInitial labs showed:
\nLeukocytosis with neutrophilia
\nNegative autoimmune serology
\nNo signs of infection
\nCorticosteroid therapy was initiated. Within 24 to 48 hours, the lesions improved significantly and pain diminished.<\/p>\n","protected":false},"excerpt":{"rendered":"
Sweet Syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder with systemic manifestations. Although uncommon, it is critical for primary care physicians to recognize its clinical signs and consider it during differential diagnosis\u2014especially when symptoms rapidly follow medication changes. This article outlines a documented clinical case and offers a comprehensive […]<\/p>\n","protected":false},"author":1,"featured_media":2553,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2552","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts\/2552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2552"}],"version-history":[{"count":1,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts\/2552\/revisions"}],"predecessor-version":[{"id":2554,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/posts\/2552\/revisions\/2554"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=\/wp\/v2\/media\/2553"}],"wp:attachment":[{"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/timeshow.xyz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}